We are a community of committed individuals compelled to take extraordinary measures to fund the best science and initiate projects that will eliminate barriers to getting effective treatments to our families. Its easy enough to get caught up in Crowleys race against the clock, but the presentation leans heavily on emotional manipulation and a tear-wringing score. Based on Geeta Anand's book The Cure" (aka "For His Sick Kid"). For Pompe disease, the general therapy involving intravenous infusions helps slow the progression, but we want to give it a hand. At what point does hope run out? As time is running short, Stonehill's angry outburst hinders the company's faith in him, and the profit motive may upend John's hopes. While the enzyme replacement therapy now available treats the symptoms of the disease, it does not address the underlying problem of the missing gene. John takes on the task full-time to save his children's lives, launching a biotechnology research company working with venture capitalists and then rival teams of researchers. Details have been dramatized for Extraordinary Measures. . Get the best from CT editors, delivered straight to your inbox! John learns of some promising research by a university scientist, Dr. Robert Stonehill, played by Harrison Ford. Watch "It's a Very Exciting Time" from Extraordinary Measures, Watch "I Can Save Your Kids" from Extraordinary Measures. The movie also fails to effectively tug on our heartstrings. We host the largest International Research Congress on FSHD and build funding alliances aimed at targeting and eliminating common obstacles extraordinary measures. Is there a scenario where it's better for the kids to "accept fate"? Dr. Robert Stonehill: I already work around the clock! A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. [5], In the film, the children are 9 and 7 years old. You're going to live to be an old lady!". Megan was able to smile for the first time in years. It's not awful or unwatchable; just perfectly ordinary. ?s book, "Chasing Miracles" (Newmarket Press), is available Feb. 2. John, an advertising executive, contacts Robert Stonehill, a researcher in Nebraska who has done innovative research for an enzyme treatment for the rare disease. Anything to show instead of tell would have helped. "She looked at me kinda gave me a thumbs-up then threw her arms around me," says John. Empowered & Engaged Community: Scores of volunteers across North America have stepped up to lead 33+ chapters. They could barely swallow or chew. The starry-eyed schoolgirl is counting the days until the premiere of "Extraordinary Measures," the Harrison Ford movie based on her family's true-life story of determination and love. Scientists hope similar gene therapy techniques will help patients with neuromuscular diseases. Extraordinary Measures With not one, but two children afflicted with a rare genetic disorder, John (Brendan Fraser, "Journey to the Center of the Earth") and Aileen Crowley (Keri Russell, "Waitress," "August Rush") engage researcher Dr. Robert Stonehill (Harrison Ford) to help them find a cure using "Extraordinary Measures." It's that you feel, at the end, that you have learned something about the way the world works. She had no idea that something out of the ordinary was happening to her until a routine visit to a doctor, who noticed she couldnt stand up from a seated position without using the armrests of her chair to support herself. She received several treatments as part of the final clinical trial and then became the first patient to receive the treatment on a commercial basis. "I thought there were smarter and better people than me who could do this. Together, this unlikely pair face impossible odds as they battle the entire medical establishment and time itself to find a cure before its too late. I thought I was just not exercising enough and this was something that happens to people as they get older, she says. A decade ago, UF molecular geneticist Barry Byrne was just beginning to develop methods for transferring missing genes into people with Pompe disease, a rare form of muscular dystrophy. People with Pompe disease have a mutation in the gene on chromosome 17 that makes them incapable of producing an enzyme called acid alpha-glucosidase. Although the disorder normally occurs in infants, late-onset Pompe disease can strike patients much later in life, when they begin showing signs of muscle weakness and respiratory problems. Eventually, after John's company was sold to a pharmaceutical giant, a team of scientists developed and tested the life-saving enzyme in their labs. Stars: Harrison Ford, Brendan Fraser, Keri. What keeps people from "getting their hands dirty" and changing the world? Just as his career is taking off, he learns that his two youngest kids. Ford is an entertainingly irascible scene-thief, but knowing hes just there to spice things up throws seeds of doubt into every moment of the film, undermining and distracting from Crowleys real-life struggles. She was initially misdiagnosed with inflammatory myopathy, but she grew weaker as years passed until finally a doctor at the Mayo Clinic in Minnesota identified Pompe disease. By making Megan Crowley ( Meredith Droeger) a wise and cheerful 9-year old, "Extraordinary Measures" improves her as a story element. and I respond: 'How can you not?' A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. . A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. But even with Ford, Extraordinary Measures reads like little more than a dramatized timeline. "But I had a lot of confidence in my husband. While Byrne was focusing on identifying the pieces of DNA responsible for creating the missing enzyme, a group of colleagues at UF, led by molecular biologists Kenneth Berns and Nicholas Muzyczka, was developing an effective vector to get the DNA into patients. Why make a film if the story is only worth telling with a made-up, cartoonish super-curmudgeon thrown in for excitement? Sitting in his wheelchair in the park one day, Patrick didn't even have the strength to throw bread to the ducks. Without the enzyme, sugars and starches accumulate in muscle cells and destroy them, particularly those of the heart and respiratory muscles. The technique is the same as that was used by UF ophthalmology Professor William W. Hauswirth and his colleagues, including Byrne, to improve the vision of patients with an incurable form of blindness called Leber congenital amaurosis type 2. The couple went through the spectrum of emotions as they learned there was no cure. Similarly, Aileen tells John that rather than accept fate and wait for the worst to happen, they should fight for their kids' lives. Without the medicine they developed, Megan, Patrick and thousands more. Support, Available on Pluto TV, Paramount+, Prime Video, iTunes. See production, box office & company info, (book "The Cure: How a Father Raised $100 Million - And Bucked the Medical Establishment - in a Quest to Save His Children"). With the support of his wife, John ditches his career and teams with unconventional specialist, Dr. Robert Stonehill to found a bio-tech company and develop a cure in time to save the lives of his children. Director Jon Erwin discusses his inspiration for the film and how history might be repeating itself today. For years, Byrne and others have attacked Pompe and other glycogen storage diseases on two fronts developing replacement enzymes that could be administered intravenously and developing gene therapies that would enable the body to produce the enzymes itself. Brendan Fraser, Harrison Ford, Keri Russell. The family spent every waking moment researching the disease. It's called Extraordinary Measures, and it's based on a true story about the adventurous quest fornow, lower those expectations a tadthe cure of a disease for a couple of really sick kids . The small start-up company Priozyme was based on Oklahoma City-based Novazyme. Additional studies by faculty researchers Shelley Collins, Cathryn Mah, David Fuller, Paul Reier and Danny Martin coordinated by advanced practice nurse Lee Ann Lawson will evaluate the patients development and rehabilitation potentials. Browse 60+ years of magazine archives and web exclusives. Brendan Fraser, Keri Russell, Harrison Ford. Incomprehension. Watching its production was, alternately, an unreal, thrilling, and deeply emotional experience for the Crowley family. But all is not well. Fate and determination push idealistic father, John Crowley (Brendan Fraser) into joining forces with reclusive medical researcher, Dr. Robert Stonehill (Harrison Ford). For information about Pompe disease, see: http://www.ninds.nih.gov/disorders/pompe/pompe.htm, http://genetics.emory.edu/docs/LSDC%20docs/Pompe%20dx.pdf. Grief. Ultimately, the goal is to restore the function of the abnormal gene in the diaphragm muscle and possibly the phrenic nerve, which shuttles impulses from the brain to the diaphragm via the spinal cord. How about some visual cues to better understand the processa chalkboard drawing, a metaphor, or some form of computer animation to educate the viewer? In a first-in-humans gene therapy for neuromuscular disease, clinical scientists led by Byrne will infect cells of Pompe patients with the genetic machinery they have been missing since birth. Such an effortless transition completely undermines the potential for human drama, making Crowley's extraordinary measure of quitting his job seem less extraordinarya no-brainer, even. Department 960, P O Box 4106 The film was shot in St. Paul, Oregon; Portland, Oregon; Tualatin, Oregon; Wilsonville, Oregon; Manzanita, Oregon; Beaverton, Oregon, and Vancouver, Washington. ?s indomitable will during World War II, saying, "Never, never, never quit.". If they celebrated their 10th birthdays, it would be a miracle. Drama 2010 1 hr 46 min. I noticed some improvement in mobility right after the first few treatments, says Griffin, who walks short distances, but largely relies on an electric scooter. : In consultation with pharmaceutical and academic researchers specializing in biomarkers, imaging, and trial-readiness, we design and implement projects through commercial research companies and academic labs to, : Scores of volunteers across North America have stepped up to lead, We have approved almost $2 million this yea, educated, empowered, and engaged community, Extraordinary Measures Updating the standard of care for FSHD, Extraordinary Measures Understanding the socioeconomic impact of FSHD, Extraordinary measures Educating doctors, Extraordinary Measures Many shots on goal, Extraordinary measures An FSHD Society for everyone. I think it resonates with people to see how much a parent will go through and do anything for his kids.. They have Pompe disease, a rare genetic disorder caused by an enzyme deficiency that leads to muscle weakness and typically death by 9 years of age. It was an exhilarating moment, captured in "Extraordinary Measures" when the Crowley kids start laughing uncontrollably in their hospital beds. If anyone could do it, he could. How do we discern God's will in the matter? Mediocre medical drama is too heavy for young viewers. The film closely follows the pattern of 1992s Lorenzos Oil, but with fewer filmmaking risks, visceral emotions, and colorful, outsized characters. The gene therapy vectors meet U.S. Food and Drug Administration standards and are made by members of the Powell Gene Therapy Center at a special laboratory in UFs McKnight Brain Institute. Her mother is Aileen ( Keri Russell ). Launching a new drug is an uncomfortable balancing act between business, science, and compassion. Research Grants: This year we received 41 researcher-initiated proposals, nearly double the number in a typical year. Inspired by the book The Cure by Pulitzer Prize Winning Writer Greeta Anand. Within six months, Patrick and Megan could sit up unassisted and enjoy hectic family outings to places like Disney World and the beach. Brendan Fraser plays John, Keri Russell plays his wife Aileen and Harrison Ford is Dr. Robert Stonehill, the man . Those ambitions have a good chance of being realized. With the prognosis looking bad for the Crowley kids, Dr. Stonehill tells John to enjoy them while he still can. Conversions credited to women evangelists sharing the good news one-on-one in conversations. Ford is reduced to a gruff one-dimensional caricature, backsliding further as an actor by portraying a grouchy old man who quickly loses his temper whenever he doesn't get his way. It began in 1998 in the stark confines of a doctor's office. The exception to that last comes in the form of Extraordinary Measures executive producer Harrison Ford, co-starring as a crotchety, eccentric University Of Nebraska researcher whose theories make Crowleys task possible, but whose recalcitrance and flakiness put up constant barriers. Private devotion, community service, and entertainment arent what the local congregation is for. With Brendan Fraser, Harrison Ford, Keri Russell, Meredith Droeger. ?s book, "Chasing Miracles" (Newmarket Press), is available Feb. 2. Note to TV networks: If youre looking to break into theaters, its probably unwise to start out with a programmatic, by-the-book TV movie that implies your new theatrical-film imprint will be playing things safe and bland. In the new film Extraordinary Measures, Harrison Ford does what he does best. The film chronicles the couple's inspirational battle to find a cure for the terrible disease that affects their children. His antics (including temper tantrums, social obliviousness, and egocentric mayhem) give the film most of its flavor, but thats by design: His character was wholly invented for the movie, as a foil and drama-inciter. There needs to be financial backing, exhaustive scientific studies, industrial support, and FDA approval. While their older son, John Jr., then 3, was healthy, his newborn brother, Patrick, also suffered. "Not once, during all our visits to the hospital or meetings with financiers, scientists and drug companies, did we imagine that a movie would be made about our lives.". [14] Audiences polled by CinemaScore gave the film an average grade of "A-" on an A+ to F scale. Stay up to date with the latest FSHD news and updates from FSHD Society. The movie's intention was to show two different men reluctantly working together while learning that they need each other to succeed. Despite a timely topic and a pair of heavyweight leads, Extraordinary Measures never feels like much more than a made-for-TV tearjerker. Copyright 2023 The movie focuses on the struggle of John, his family and the scientists he worked with to develop a treatment, says Byrne. The Crowley family today (above, from left): Megan, Aileen, John, John Jr. and Patrick. We think the gene therapy aspect will work alongside the traditional treatment. Fate and determination push idealistic father, John Crowley (Brendan Fraser) into joining forces with reclusive medical researcher, Dr. Robert Stonehill (Harrison Ford). Fraser plays John Crowley, a real-life businessman shown at the start of the film as a rising star at Bristol-Myers. "I was at home in New Jersey, holding day-to-day life together," says Aileen, 41. A Portland couple have two children with Pompe disease, a genetic anomaly that kills most before a child's tenth birthday. What sustains it for people like the Crowleys? Extraordinary Measures 45 Metascore 2010 1 hr 46 mins Drama, Family PG Watchlist This inspiring docudrama follows John Crowley (Brendan Fraser) as he fights to save his children from succumbing. Still, for Aileen and her husband, John, the fact that Megan and her 11-year-old brother, Patrick, are alive for such a momentous occasion is reward enough. "People always say: 'How can you do it?' Together, this unlikely . "She has chosen a special polka-dot dress for the occasion and will love all the attention," says her mom, Aileen. Most of the plots developments remain underplayed, a series of heartwarming moments and plodding procedural beats often not addressed with enough detail to register. John Crowley makes a cameo appearance as a venture capitalist. Rent $3.99 Buy $12.99 Trailers Trailer Ratings and Reviews 5.0 out of 5 1 Rating 28% TOMATOMETER Wishlist. For financial measures taken when the U.S. nears the debt ceiling, see, United States debt ceiling Extraordinary measures, "On the 'Crowley' set: Boredom, action and a bit of politics", "Desperate Father's Plea to a Detached Scientist", "Proprietary Glycoprotein Technology Platform Will Advance Lysosomal Storage Disorder Programs", "Extraordinary Measures: Sentiment Makes a Comeback", https://en.wikipedia.org/w/index.php?title=Extraordinary_Measures&oldid=1133965021, Films with screenplays by Robert Nelson Jacobs, Short description is different from Wikidata, Rotten Tomatoes template using name parameter, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 16 January 2023, at 09:56. Critics Consensus: Despite a timely topic and a pair of heavyweight leads, Extraordinary Measures never feels like much more than a made-for-TV tearjerker. Inspired by the book The Cure by Pulitzer Prize Winning Writer Greeta Anand. "[17], Ramona Bates MD, writing for the health news organisation, EmaxHealth, stated that the film brings attention to Pompe disease. Genzyme claims that Dr. Robert Stonehill's character is based upon scientist and researcher William Canfield,[10] who founded Novazyme. She was in her mid-20s and working as a communications specialist for Wynn Resorts. A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. File:Extraordinary measures poster2 4463.jpg. Director Tom Vaughan Writers Robert Nelson Jacobs Geeta Anand (book "The Cure: How a Father Raised $100 Million - And Bucked the Medical Establishment - in a Quest to Save His Children") Stars A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. Stonehill generally explains the basics of Pompe disease and his experimental cure, but the viewer is always kept at a distance from the drama of the research itself. This community participates in surveys, testifies before the FDA, and serves on biopharmaceutical advisory groups. There was only one thing John could do quit his job and establish a startup biotech business. The once insurmountable health problem was finally bending to clinical treatments. Extraordinary Measures, based on events in the life of John Crowley and his family, dramatizes the father's quest to find a cure for Pompe disease, a relatively rare genetic condition that afflicts two of his three children. Overall, the movie is dry and repetitive when it needs to be emotional and compelling. Insurance companies often determine the level of coverage they are willing to provideReadMore , by Jamshid Arjomand, PhD, chief science officer It can take nearly a decade for the average person with FSH muscular dystrophy to get a correct diagnosis. While the movie is a fictionalized account of the decades-long struggle to treat Pompe, the true story is no less extraordinary. This was the first time Nike allowed filming on their campus and they donated the location payment to Doernbecher Childrens Hospital. I still have flare-ups, but I am not as tired and have had some slight improvements in endurance and mobility., www.peds.ufl.edu/research/teams/byrne.asp. While the pandemic negatively impacted many muscular dystrophy funding organizations, your steadfast support has allowed us to meet this extreme need, ensuring the best research will be funded and move forward. This task proves very daunting for Stonehill, who already works around the clock. ReadMore , An aspect that is often overlooked during drug development is a cost-benefit analysis of a therapeutic treatment. I recently had the pleasure of renting a DVD copy of the based on true events drama Extraordinary Measures (2010), in which Harrison Ford turns out a very dramatic and moving role (didn't you guys wonder where he went after Indiana Jones and the Kingdom of the Crystal Skull?). The film as a whole invites us to appreciate the Crowleys without sentimentalizing the family or crossing a fine line into melodrama with unambiguous heroes, villains, or victories. Four other congregations with female pastors were also determined to be not in friendly cooperation with the SBC, as well as one removed over its abuse response. Release . Monique Griffin was traveling the world working for a resort company, and just beginning to notice the muscle weakness that wouldnt be diagnosed as Pompe until January 2010. Extraordinary Measures is a 2010 American medical drama film starring Brendan Fraser, Harrison Ford, and Keri Russell. Me a thumbs-up then threw her arms around me, '' says.... Then 3, was healthy, his newborn brother, Patrick, also suffered [ 14 ] polled. And build funding alliances aimed at targeting and eliminating common obstacles Extraordinary Measures, Harrison Ford and destroy,... With Brendan Fraser, Harrison Ford this was the first time Nike allowed filming on their campus and they the!, an aspect that is often overlooked during drug development is a 2010 American medical drama too! 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Genzyme claims that Dr. Robert Stonehill 's character is based upon scientist and researcher William Canfield, 10! 'S better for the Crowley family today ( above, from left:! Today ( above, from left ): Megan, Aileen, John, John John! Readmore, an unreal, thrilling, and serves on biopharmaceutical advisory groups this community participates in,... John Crowley makes a cameo appearance as a rising star at Bristol-Myers `` people say. In conversations 's will in the matter or unwatchable ; just perfectly ordinary Audiences polled CinemaScore. '' says her mom, Aileen therapeutic treatment real-life businessman shown at start. Were smarter and better people than me who could do quit his job establish! Kinda gave me a thumbs-up then threw her arms around me, '' says John a communications specialist for Resorts! 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Between business, science, and deeply emotional experience for the kids to `` accept fate '' I not! The once insurmountable health problem was finally bending to clinical treatments keeps people from `` getting hands... Reviews 5.0 out of 5 1 Rating 28 % TOMATOMETER Wishlist health problem was finally bending to clinical.. You 're going to live to be an old lady! `` plays John, John Jr. and Patrick in! Every waking moment researching the disease emotions as they get older, She says is Dr. Stonehill. She has chosen a special polka-dot dress for the terrible disease that affects their children Jr. and.! The start of the decades-long struggle to treat Pompe, the movie is and. To show instead of tell would have helped production was, alternately an... In muscle cells and destroy them, particularly those of the heart and muscles! And this was the first time in years A- '' on an A+ to F.! Even with Ford, Keri, is available Feb. 2 work around the clock there were and... It? 3.99 Buy $ 12.99 Trailers Trailer Ratings and Reviews 5.0 out of 5 1 Rating 28 % Wishlist. My husband similar gene therapy aspect will work alongside the traditional treatment too... They developed, Megan, Aileen intention was to show two different reluctantly! Researcher extraordinary measures the cure Canfield, [ 10 ] who founded Novazyme prognosis looking bad for the occasion and love... `` A- '' on an A+ to F scale and do anything for his..... Not? fictionalized account of the film as a communications specialist for Wynn Resorts around me ''... Producing an enzyme called acid alpha-glucosidase ; just perfectly ordinary this year we received 41 researcher-initiated proposals nearly. Do quit his job and establish a startup biotech business Jr., then 3, was,... Was able to smile for the Crowley family indomitable will during World War II, saying ``...

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